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An oxysterol; suppresses endogenous cholesterol synthesis by binding INSIG proteins and preventing SREBPs from being transported to the Golgi; inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM); inhibits replication of SARS-CoV-2 in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection; reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection at 100 mg/kg per day; serum levels are increased in patients with SARS-CoV-2.
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Differential Ion Mobility System Suitability Synthetic Standard Mixture. Mixture contains 1mg/ml of each lipid below (0.25mg/ml PI), 0.5ml per vial in chloroform: methanol (1:1). We recommend purchasing Bovine Heart Extract as an accompanying product.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Fluorescent DOTAP (NBD-DOTAP) is an NBD-labeled cationic lipid used for nucleic acid and protein delivery, membrane labeling, and nanocarrier tracking. The NBD fluorophore provides visible-range excitation and emission suitable for imaging and formulation research. The compound is supplied as a solid and should be protected from light and stored under the temperature conditions recommended for solvent or bulk storage.
NBD-labeled cationic lipid for delivery and imaging.
Suitable for nucleic acid and protein transfection studies.
Visible-range fluorescence (approx. 463/536 nm) for tracking.
High purity for research applications.
Stable solid form; protect from light and store under recommended conditions.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
DODMA is a cationic lipid used in the preparation of lipid nanoparticles for drug delivery. Its pH-titratable head group remains neutral at physiological pH for systemic circulation, but protonates in the acidic environment of endosomes, facilitating fusion with the endosome membrane and aiding nucleic acid release.
Cationic lipid
Can be used to prepare lipid nanoparticles
Can be used for drug delivery
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